ea0005oc2 | Reproduction and Development | BES2003
Stevens A
, Brintnell W
, Worthington J
, Zoumpoulidou G
, Jivraj S
, Regan L
, Brosens J
, Davis J
Prolactin is expressed in lymphoid cells and differentiating (decidualised) endometrial stromal cells (ESCs) under the control of an alternative upstream promoter, distinct from the pituitary-specific promoter. Local prolactin action may have immunomodulatory effects. Th1/Th2 imbalance may be an important cause of habitual abortions in man but the mechanism is unknown. Recently, we characterised a G/T SNP at position -1149 that altered prolactin production by lymphocytes, and ...